Yes, one can fatally overdose from use of methamphetamine. Increased heart rate, increased blood pressure, and vascular constriction affect many organ systems, causing heart problems, stroke, and acute kidney failure. They usually result in direct toxic effects, followed by multiple organ failure. Death from a methamphetamine overdose is associated with the rapid onset of kidney failure and collapse of the circulatory system. A large percentage of patients who die usually have symptoms of coma, shock, inability to pass and secrete urine, and muscle twitching.
Other complications associated with methamphetamine intoxication include pulmonary edema, hypoglycemia, intracerebral hemorrhage, hyperthermia, hypertension, confusion, delirium and hyperactivity.
